Abstract
Nutritional quality affects fertility in both men and women. Nutrition should be considered in the prevention and treatment of infertility in men and women. In this study, we evaluated IVF rates, oocyte maturation and oocyte quality in a female animal model feding ketogenic, western and standard type diet. Female BALB / c mice were allocated to three groups: (a) control; (b) Western and (c) Ketogenic. After feeding female mice with these 3 feeding groups for 4 weeks, IVF was administered before sacrification of the mice. The number of collected oocytes and oocyte quality, fertilization rates and embryo quality were evaluated.The number of total oocytes was the highest in the ketogenic diet and the least in the western diet. MII stage oocytes in the ketogenic group were statistically significantly higher than the control group and western groups. Fertilized oocyte count was significantly lower in the western group compared to the other two groups. When the two-cell zygote stage was evaluated, it was found that the results were better in the ketogenic diet group and worse in the western diet group. The worst results in terms of the number of zygotes reaching the blastocyst stage were observed in the western type nutrition group, and the best results were observed in the group on the keteogenic diet. The results of our study show that western nutritional models negatively affect IVF results, while ketogenic diet has a positive effect. Keywords: Fertility, ketogenic diet, oocyte, ovulation, western diet DOI: 10.7176/JMPB/72-02 Publication date: January 31 st 2022
Highlights
The diets of most expectant mothers who are planning to conceive are often inadequate
MII stage oocytes in the Ketogenic Group (KG) group were statistically significantly higher than the Control Group (CG) and Western Group: (WG) groups (p< 0.01)
When CG and WG groups were compared in terms of MII stage oocytes, the number of MII oocytes was found to be higher in favor of the CG group. this difference was not statistically significant ( p> 0.05)
Summary
The diets of most expectant mothers who are planning to conceive are often inadequate. Lifestyle factors, diet, exercise, stress, alcohol, drug use, smoking and obesity affect cycle performance during in vitro fertilization (IVF) treatments [1, 2]. Embryo development and the condition of the ovaries and endometrium, which are the main factors affecting the success of the treatment, depend on the physiology of the expectant mother. This has been demonstrated in many animal and human models in vivo [4, 5]. Nutrition types, smoking, excessive weight, exercise and stress, as well as lifestyle factors, reduce the chance of pregnancy in IVF treatments [9]. Nutrition should be considered in the prevention and treatment of infertility in men and women
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