Abstract
Objective To evaluate the efficacy and safety of topical diclofenac sodium 0.1% on femtosecond laser-assisted cataract surgery. Methods A prospective, randomised study. Ninety-six age-related cataract subjects (96 eyes) scheduled to undergo femtosecond laser-assisted cataract surgery were randomized into two groups according to the topical treatment: Group 1, study group (51 eyes), preoperative diclofenac sodium 0.1% and levofloxacin 0.5% postoperative add steroid; Group 2 (45 eyes), preoperative levofloxacin 0.5% only, postoperative add steroid, as a control group. No epinephrine was used in the intraoperative irrigation solution. Outcome measures included intraoperative change in pupil size, postoperative change in macular thickness and volume. Pupil diameter was measured three different times during surgery: in front of femtosecond laser, before the first incision formation and the end of phacoemulsification. Macular thickness was measured during the preoperative, 1 day, 7 days and 1 month postoperatively. Results The study group had smaller intraoperative pupil diameter changes compared to the control group, the differences among two groups arrived significance statistically (P 0.05), however, there were significant differences in CFS between the groups on the 1 month postoperatively (P <0.05). Conclusions Adding preoperative and postoperative diclofenac sodium 0.1% to topical treatment can reduce intraoperative miosis and macular change more effectively than postoperative steroid alone. Key words: Diclofenac sodium; Miosis; Macular edema; Femtosecond laser-assisted cataract surgery
Published Version
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