Abstract
The in vitro effects of Combretum zeyheri leaf ethanol extract (CZLE) on ergosterol biosynthesis of Candida albicans were investigated by quantifying the ergosterol in C. albicans in the presence and absence of the extract using UV-visible spectrophotometric analyses. Miconazole was used as the positive control. CZLE showed ergosterol biosynthesis inhibition at sub-inhibitory concentration for growth of C. albicans and also at the MIC (0.08 mg.mL−1). The decrease in ergosterol in C. albicans cells was dose-dependant with 67%, 79%, and 100% after growing in 20, 40, and 80 μg.mL−1 of CZLE, respectively. CZLE exerted its fungicidal effects by targeting the ergosterol biosynthesis in C. albicans and disrupting the membrane integrity.
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