The effects of arm cranking exercise and training on platelet aggregation in male spinal cord individuals

Abstract

Platelet aggregation at rest and in responses to exercise and training were compared between spinal cord injured (SCI) individuals ( N=5) and able-bodied subjects ( N=7). All participants performed arm cranking exercise at 60–65% VO 2peak for 30 min. Venous blood samples were obtained before and after sub-maximal exercise and measured for platelet aggregation using ADP and collagen. To assess the effects of arm cranking training, platelet aggregation was re-measured in all subjects at rest and in response to the sub-maximal arm cranking exercise after 12 weeks of individually supervised training programme. Before training, the resting mean values of platelet aggregation induced by ADP and collagen were not different ( P>0.05) between SCI and able-bodied. However the SCI individuals, but not the able-bodied subjects, exhibited a significantly ( P<0.05) higher maximal platelet aggregation induced by ADP and collagen following sub-maximal arm cranking exercise. Although VO 2peak after training was significantly increased ( P<0.05) in both groups, the resting mean values of platelet aggregation induced with ADP and collagen were not significantly different ( P>0.05) from those observed before training and were not different ( P>0.05) between SCI and able-bodied. Post-training, the SCI individuals, but not able-bodied individuals, exhibited a significant decrease ( P<0.05) in platelet aggregation following sub-maximal arm cranking exercise and this occurred with both ADP and collagen. These results suggest that SCI individuals, but not normal subjects increase their platelet aggregation following sub-maximal arm cranking exercise. Furthermore, arm cranking training in SCI individuals, appears to diminish the percentage of platelet aggregation ex vivo.