Abstract
A new drug, hexobendine, when injected intravenously, produced an increase in cerebral blood flow (CBF) of approximately 15% accompanied by a decrease in cerebral vascular resistance (CVR) which persisted for 35 min. The effective intravenous dosage was 1.5 mg/kg, and following intraduodenal injection, 4 mg/kg were comparatively effective. The mean arterial blood pressure (MABP) was decreased. There was a small but significant increase in the cerebral metabolic rate for oxygen (CMRO 2) for the first 5 min following injection of the drug. It is believed that the drug may have a direct effect on cerebral metabolism just as reports from other laboratories suggest that the drug increases myocardial metabolism. The CBF was also increased following the intraduodenal administration of hexobendine; this began 20 min after the drug was given and persisted for 70 min in some animals. Hexobendine appears to be a potent and long-lasting cerebral vasodilator drug when administered either intravenously or orally.
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