Abstract
ABSTRACT Studies have demonstrated that the consumption of a high-fat diet (HFD) is linked to a higher occurrence of obesity and metabolic disorders. Maternal dietary habits can have long-lasting effects on the health of offspring. This study aimed to evaluate the impact of a HFD on the liver of pregnant rats and their offspring. 30 pregnant rats were used in this study. They were divided into two equal groups; control and HFD group. HFD group were fed on 15% lard from 6th week before conception till the end of weaning period. The mother rats and their offspring were sacrificed; blood samples were collected for estimation of biochemical parameters. The liver was removed for histological, immunohistochemical, and ultrastructural investigations. HFD mothers displayed elevated serum levels of LDL, triglycerides and total cholesterol and elevated blood glucose compared to the control. Also, remarkable histopathological and ultrastructural signs were recorded in the liver tissue of HFD treated mothers and their offspring. Additionally, the liver tissue displayed strong expression for caspase 3 and obvious reduction for PCNA. These results emphasize the importance of a balanced diet during pregnancy to prevent long-term liver complications in both mothers and their offspring.
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