The effectiveness of using a combination of laser radiation with wavelengths of 585 nm and 1064 nm in the treatment of patients with basal cell skin cancer.

Abstract

Background: Basal cell skin cancer is the most common skin malignancy, and its incidence has been rapidly increasing throughout the world in recent decades.
 Aims: To study the effectiveness of using laser radiation with a wavelength of 585 nm and 1064 nm in a sequential (sequential) combined mode for the treatment of patients with superficial and nodular forms of basal cell skin cancer using dermoscopic and confocal microscopic in vivo examination.
 Materials and methods: The study included 30 patients with histologically confirmed basal cell skin cancer, who received treatment in the conditions of the Consultative and Diagnostic Center of the State Research Center of Dermatovenereology and Cosmetology of Russian Ministry of Health in the period from 2020 to 2021, using a pulsed dye laser (wavelength 585 nm) and long-pulse neodymium laser (wavelength 1064 nm).
 Results: In the subgroup of patients with the nodular form of basal cell carcinoma (n=15): in 11 patients the duration of treatment was 1 procedure, in 3 patients 2 procedures, in 1 patient 3 procedures. In the subgroup of patients with superficial basal cell carcinoma (n=15 ): in 2 patients the course of treatment was 2 procedures, in 13 patients 1 procedure. Patients have now completed treatment and are being followed up with visits every 6 months for 3 years. According to dermoscopic and confocal microscopic studies, there is no evidence of continued growth and relapse in all patients. No side effects or adverse events were recorded.
 Conclusions: The combined sequential use of 585 nm and 1064 nm laser radiation may be an effective treatment for patients with low-risk basal cell skin cancer of recurrence. The results of our study indicate that clinical tumor removal without scarring can be achieved and may be an alternative treatment option for those who do not wish to use traditional surgical approaches.