Abstract
Objectives: The purpose of this research was to determine the difference in the effectiveness of mouthwash of red betel leaf extract on the dental plaque index.
 Design:This research design is Quasi experimental. The ethanol extract of red betel leaf was prepared in various concentrations for use by the correspondents as a mouthwash. Dental plaque was observed before and after treatment, then compared the differences in results between groups.
 Interventions:The intervention variable in this study was a mouthwash preparation containing 4% and 5% ethanol extract of red betel leaf, then compared with a positive control mouthwash preparation containing Chlorhexidine.
 Main outcome measure:The results showed a decrease in the dental plaque index in the correspondents who were given mouthwash containing 4% and 5% red betel leaf ethanol extract. The anova test showed a significant difference between the dental plaque index between before and after treatment (p <0.05).
 Conclusion:Mouthwash containing ethanol extract of red betel leaves is effective in reducing the dental plaque index value.
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