Abstract
To evaluate the effectiveness of inhaled corticosteroid therapy in asthmatic children in the age group of 0-6 years. Systematic review of randomised double blind placebo controlled trials of inhaled corticosteroid therapy for preschool children with asthma. 12 Trials were identified for this review. Data on symptom scores, parents' sleep disturbance, parents' assessment of asthma status/medication, concomitant drug use, exacerbation rate, lung function measurement, and adverse effects were retrieved form the trials. Most parallel trials showed significant improvements in symptom scores, concomitant drug use, exacerbation rate, or lung function measurements. Most improvements were seen in wheeze and concomitant drug use. The pooled odds ratio (95% confidence interval (CI)) for outcome measure 'patients with at least one exacerbation' was 0.47 (0.3 to 0.73). Two crossover trials showed significant improvements in symptom scores, ß-agonist use, and lung function. Significant differences in adverse effects between the active and placebo groups were not detected. In conclusion, this systematic review of literature shows beneficial effects on symptoms, exacerbation rate, and pulmonary function for the use of inhaled corticosteroids in preschool children with asthma.
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