THE EFFECTIVENESS OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER IN WOMEN SUFFERING FROM NON-SPECIFIC CHRONIC ENDOMETRITIS

Abstract

Aim. To estimate prevalence of chronic endometritis among women with repeated implantation failures in vitro fertilization and embryo transfer (IVF and ET), as well as to assess the impact of timely diagnosis and comprehensive treatment of chronic endometritis on the success of implantation. Materials and methods. 55 women with two or more failed IVF and ET cycles comprised the study group. All patients underwent hysteroscopy and endometrial sampling for histology, immunohistochemistry and microbiological investigations. 3D ultrasound measurements of uterine cavity were applied. All women diagnosed with chronic endometritis underwent complex treatment and the effect of treatment was confirmed by hysteroscopy with biopsy. After treatment, all women had a further IVF attempt. The effectiveness of treatment was estimated using clinical pregnancy rate. Results. The diagnosis of chronic endometritis was confirmed be immunohistochemistry in 96,4% of women. In 16,9% of these cases hyperplastic endometrial polyps were also revealed. Those patients underwent another hysteroscopy and polypectomy. In 54,0% of cases intensity of chronic endometritis was estimated as high. Clinical pregnancy had been confirmed in 41,2% of women after complex treatment. Conclusion. Results of this research demonstrate that chronic endometritis is a state frequently associated with repeated implantation failures. The normalization of the hysteroscopic endometrial pattern was associated with a significant improvement of the reproductive outcome of the IVF and ET cycle performed after treatment.