The effect of vit D3 deficiency on increased incidence of convulsion in epileptic patients

Abstract

Epilepsy is a common neurological disorder affecting all age groups We sought to assess the longitudinal effect of antiepileptic drug on serum 25-hydroxyvitamin D [25(OH)D], with recurrent attack of epileptic fits. The study consisted of two parallel, 1-year, prospective, randomized, dose-ranging trials conducted in two groups of ambulatory patients, for 46 patients based on clinical presentation of the patient together with confirmed diagnosis by EEG. The patients improved when maintenance dose of Vit D3 with daily taken to restore the normal level, with measurements for all patient 95 % of patient recovered from an epileptic fits with increase the level of Vit D3 to the normal value. In conclusions, majority of the patients should be treated with an escalating regimen of vitamin D, with doses varying between 400 and 15,000 IU/day.