Abstract
The level of tryptophan and 5-hydroxyindoleacetic acid were measured in the brain (striatum) of rats on tryptophan-deficient diet and tryptophan-enriched diet. We measured concentrations of tryptophan and 5-hydroxyindoleacetic acid in striatum by using microdialysis and HPLC methods. The extracellular level of tryptophan and 5-hydroxyindoleacetic acid concentration in the striatum of a tryptophan-reduced rats was decreased by about 50% compared with a tryptophan-enriched diet. In the tryptophan-reduced condition, the rats an increased the running time of more than 100 min, compared with those on a tryptophan-enriched diet. These results suggest the tryptophan and 5-hydroxytryptamine in the central nervous system are involved in fatigue.
Published Version
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