Abstract
During hyperthermia, magnetite nanoparticles placed in an AC magnetic field become a source of heat. It has been shown that in fluid suspensions, magnetic particles move freely and generate heat easily. However, in tissues of different mechanical properties, nanoparticle movement is limited and leads to a small temperature rise in tissue. Therefore, it is crucial to conduct magnetic hyperthermia experiments in similar conditions to the human body. The effect of tissue-mimicking phantom compressibility on the effectiveness of magnetic hyperthermia was investigated on agar phantoms. Single and cluster nanoparticles were synthesized and used as magnetic materials. The prepared magnetic materials were characterized by transmission electron microscopy (TEM), and zeta potential measurements. Results show that tissue-mimicking phantom compressibility decreases with the concentration of agar. Moreover, the lower the compressibility, the lower the thermal effect of magnetic hyperthermia. Specific absorption rate (SAR) values also proved our assumption that tissue-mimicking phantom compressibility affects magnetic losses in the alternating magnetic field (AMF).
Highlights
Iron oxide nanoparticles in tumor tissues can act as a heat source because of their intrinsic magnetic features and nanosize
We demonstrated that an environment in which nanoparticles are embedded affects the temperature increase during magnetic hyperthermia
Two types of magnetic materials were synthetized to be utilized in our experiments, single nanoparticles (SNPs) and nanosphere cluster nanoparticles (CNPs) composed of small magnetite nanograins
Summary
Iron oxide nanoparticles in tumor tissues can act as a heat source because of their intrinsic magnetic features and nanosize. Heat transferred from the nanoparticles to the tissue increases its temperature. Magnetic hyperthermia experiments with nanoparticles should be performed in materials with different elastic properties. To test this phenomenon, tissue-mimicking phantoms (hydrogel) may be used. Agar-based tissue-mimicking materials are specially developed systems that mimic the physical properties of various human tissues. They have been invaluable for developing and testing the thermal effects of hyperthermia [14]. We analyzed how mechanical properties, such as compressibility, affect magnetic losses in the alternating magnetic field. We demonstrated that an environment in which nanoparticles are embedded affects the temperature increase during magnetic hyperthermia
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
