Abstract
The fact that the injection of thyrotropic hormone results in an increased metabolism of intact animals has been thoroughly established by many researches (1, 2, 3, 4, 5). Similar results have been obtained in human beings. There is also ample evidence that the injection of the hormone causes hyperplasia of the thyroid, with reduction and vacuolization of the colloid. While the increased total metabolism of the animal naturally depends upon the increased metabolism of individual tissues, it is of course possible that the latter effect might be dependent upon the integrity of the animal, and might not be manifest when the tissues are isolated. Only Paal (6) has investigated this. He observed that after 3 days’ injection of anterior pituitary extract into guinea pigs, the O2 consumption of thyroid tissue taken from such animals was 3 to 4 times as great as that of normal guinea pig thyroid tissue, and that this effect was also to be seen to a lesser extent in other tissues. A few experiments have also been ...
Published Version
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