Abstract
Background & Objective:The relationship between thyroid disorders and dyslipidemia has now been clearly demonstrated, but the relationship between thyroid autoimmunity and dyslipidemia in euthyroid patients is still controversial. Our aim in this study was to determine whether there is a risk of dyslipidemia in our patients with euthyroid hashimoto thyroiditis.Methods:Fifty-five autoantibody positive hashimoto patients and 55 antibody negative control groups who came to Sakarya University Medicine Faculty Endocrinology Outpatient Clinics between January 2018 and November 2019 were included in our case control study. The groups were similar in terms of age, cardiovascular risk factors and BMI. Both groups were compared according to the lipid profile results.Results:All type of lipids; including LDL (p = 0.008), HDL (p = 0.041), triglyceride (p = 0.045) and total cholesterol (p = 0.002), were higher in the patient group, and these differences were statistically significant. Anti-TPO and Anti-TG antibody titers and lipid levels were evaluated by separate correlation analysis. There was a significant positive correlation between Anti-TPO and LDL (r = 0.331, p <0.001), triglyceride (r = 0.267, p = 0.005) and total cholesterol (r = 0.316, p = 0.001), however no significant correlation was observed between Anti-TPO and HDL. Similarly, there was a significant positive correlation between Anti-TG and LDL (r = 0.318, p = 0.001), triglyceride (r = 0.218, p = 0.022), and total cholesterol (r = 0.301, p = 0.001), but HDL correlation relationship was not detected.Conclusion:The relationship between thyroid autoimmunity and dyslipidemia has been demonstrated in our study even in the euthyroid phase. Whether antibody positive patients should be followed more closely for dyslipidemia and cardiovascular events is still controversial. This question will be answered with larger randomized controlled trials.
Highlights
Chronic lymphocytic thyroiditis (Hashimoto thyroiditis); is the most common organ-specific autoimmune disease and the most common cause of thyroid dysfunction in iodine sufficient areas.[1]
The mean age was calculated as 28.8 ± 8.3 in the patient group and 27.5 ± 7.8 in the control group (p = 0.400)
We clearly demonstrated the effect of thyroid autoimmunity on atherogenic lipid profile which is independent of thyroid dysfunction
Summary
Chronic lymphocytic thyroiditis (Hashimoto thyroiditis); is the most common organ-specific autoimmune disease and the most common cause of thyroid dysfunction in iodine sufficient areas.[1]. Dyslipidemia is the presence of high quality and quantity lipid and lipid metabolites in the circulation due to congenital or acquired reasons It is not clinically symptomatic usually, it is detected by chance in laboratory tests or it is noticed by vascular complications as a result of atherosclerosis secondary to dyslipidemia. Results: All type of lipids; including LDL (p = 0.008), HDL (p = 0.041), triglyceride (p = 0.045) and total cholesterol (p = 0.002), were higher in the patient group, and these differences were statistically significant. Whether antibody positive patients should be followed more closely for dyslipidemia and cardiovascular events is still controversial. This question will be answered with larger randomized controlled trials
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