Abstract

The possibility of increasing the blood-compatibility of polymers by fixation on the surface of the latter, of the proteolytic enzymes trypsin, chimotrypsin, fibrinolysin and the protease from actinomycetes, has been studied. Methods have been developed for fixation of the enzymes on polymers. It is shown that fixation of fibrinolysin and protease by grafting these enzymes modified with acrylyl chloride, to polymers in the presence of a hydrophilic comonomer, results in formation of highly active, stable preparations, displaying high compatibility with blood.

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