Abstract
Determination of alkaline phosphatase (ALP) isoenzyme activity is useful for the diagnosis and clinical evaluation of cancer patients, including breast cancer. 21 women were randomized to receive tamoxifen , probably the most widely used endocrine treatment for breast cancer worldwide, for 2 years, and 21 women constituted the control group. Control group were treated without Tamoxifen considering placebo effect. Alkaline phosphatase level was significantly lower in tamoxifen treated female breast cancer patients when compared with those of the treated patients with placebo. Results indicates that the tamoxifen decrease the level of ALP in first three months and then stabilize this level in the following months.
Highlights
Breast cancer is the most common cancer in the female population which originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. [1]
Since the alkaline phosphatase (ALP) level in breast cancer patients is proper marker, this study aims to analyze the change of ALP level with the tamoxifen treatment in order to see tamoxifen effect on ALP level
Two-way Repeated Measures Analysis of Variance showed that alkaline phosphatase level were significantly lower in tamoxifen treated female breast cancer patients when compared with those of the treated patients with placebo
Summary
Breast cancer is the most common cancer in the female population which originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. [1]. Even though great progress in the treatment of breast cancer has been achieved during past decades, it is still the principal cause of cancer death among women worldwide [2,3]. Alkaline phosphatase (ALP) comprises a group of isoenzymes. These enzymes have some important function like hydrolyzing of phosphate esters in an alkaline environment. They generate an inorganic phosphate and organic radicals [4].The total serum alkaline phosphatase activity represents several isoenzymes in different organs. ALP is a sensitive indicator of mild biliary obstruction, being a very sensitive indicator of liver progression in cancer patients. [5] Manys studies reveal that the determination of alkaline phosphatase (ALP) ALP is a sensitive indicator of mild biliary obstruction, being a very sensitive indicator of liver progression in cancer patients. [5] Manys studies reveal that the determination of alkaline phosphatase (ALP)
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