Abstract
Several studies found that the probiotic bacterias such as Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 could prevent glycemia and control the blood lipid profiles. Currently, a probiotic product such as yogurt is not preferable by some consumers since the taste is sour. Therefore, this study was conducted to develop milkshakes supplemented by probiotics Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 which are expected to be more acceptable and have a beneficial effect with the addition of prebiotics and soluble fiber glucomannan. This study aims to determine the effect of synbiotic shakes on fasting blood glucose levels and lipid profiles in hyperglycemia Wistar rat models. The study design was a pre-posttest controlled group with 48 male Wistar rats divided into 8 groups, namely the healthy control group (I); hyperglycemia control group (II); group III that received metformin; group IV that received synbiotic shake with La5 + FOS; group V that received synbiotic shake La5 + inulin; group VI that received synbiotic shake Bb12 + FOS; group VII that received synbiotic shake Bb12 + inulin; and group VIII that received synbiotic shake La5 + Bb12 + FOS. The dose of the intervention was 3.6 ml/day with an intervention duration of 28 days. The results showed that the differences in blood glucose levels were not significant (p> 0.05) except for groups IV and VI that experienced a significant increase (p <0.05). The differences in lipid profiles showed insignificant changes in LDL levels except in groups IV and V, a significant increase in HDL levels (p <0.05) in group V and VI, and insignificant change in triglycerides except in group VI. It can be concluded that the administration of synbiotic shakes with a variety of prebiotics Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 for 4 weeks were able to maintain fasting blood glucose levels and lipid profiles in hyperglycemic rats.
Highlights
Hyperglycemia is a condition where high blood glucose levels exceeding the normal range continuously and are commonly associated with diabetes mellitus [1]
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels due to impaired insulin secretion, impaired insulin utilization, or both [2]
We developed synbiotic shakes, which is a type of milk-based drink containing Lactobacillus acidophilus or Bifidobacterium lactis as well as prebiotics fructooligosaccharide and inulin and soluble fiber glucomannan, that expected to affect on fasting blood glucose (FBG) levels and lipid profiles
Summary
Hyperglycemia is a condition where high blood glucose levels exceeding the normal range continuously and are commonly associated with diabetes mellitus [1]. Diabetes mellitus is a metabolic disease characterized by high blood glucose levels due to impaired insulin secretion, impaired insulin utilization, or both [2]. Diabetes mellitus type 2 is exclaimed the silent killer because it could increase the risk of various complications. The various complications that would happen such as retinopathy, heart disease, kidney problems, infections, blood vessel disorders, strokes, and many more. As a result of complications from the disease, people with diabetes mellitus will experience a decrease in quality of life and even increase the risk of mortality [3,4]. Cardiovascular disease is the principal cause of death in people with diabetes mellitus type 2 because the risk of developing cardiovascular disease in people with diabetes mellitus type 2 is two to four times higher than that of cardiovascular disease in non-diabetic people
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