Abstract
Certain 3-alkylaminopropionitriles are highly active against TMV (tobacco mosaic virus) multiplication in leaf disks, local lesion production by TMV on Nicotiana glutinosa L. and beans ( Phaseolus vulgaris L. var. Pinto), and local lesion production by TRV (tobacco ringspot virus) on Pinto beans. Maximum activity in both types of test occurs with straight-chain alkyl derivatives having 12–14 carbon atoms, and antiviral activity is progressively lower with compounds having longer or shorter substituents. Although appreciable activity is found at concentrations of the chemicals that are not visibly phytotoxic, and respiration is not inhibited when virus multiplication is severely curtailed, cytotoxicity has not been definitely excluded as a contributor to the antiviral effect.
Published Version
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