Abstract
β-Tricalcium phosphate (TCP) is a type of bioceramic material which is commonly used for hard tissue repair and famous of its remarkable biocompatibility and osteoconductivity with similar composition to natural bone. However, TCP lacks osteoindcutive properties. Stromal-derived factor 1α (SDF-1α) can promote bone regeneration with excellent osteoinduction effect. In this study, SDF-1α was loaded into TCP to investigate the in vitro effects of SDF-1α on the osteoinductive properties of TCP. In vitro studies showed that SDF-1α/TCP scaffold significantly stimulated the expression of osteopontin and osteocalcin. As to the in vivo studies, the rabbit bone defect model showed that SDF-1α stimulated more new bone formation. In conclusion, SDF-1α/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.
Highlights
Diseases such as infection, congenital deformity, trauma, and tumor excision can result in segmental bone defects, which always lead to dysfunction and osteogenesis obstacles [1]
The Stromal-derived factor 1α (SDF-1α)/Tricalcium phosphate (TCP) composite exhibited looser and rougher surfaces with more irregular micropores and larger crystals than TCP bioceramic scaffolds, which corresponds to the results of the specific surface of TCP
Our in vitro study showed that SDF-1α/TCP scaffolds significantly stimulated the expression of osteopontin and osteocalcin
Summary
Congenital deformity, trauma, and tumor excision can result in segmental bone defects, which always lead to dysfunction and osteogenesis obstacles [1]. Bone tissue engineering techniques that seed cells, such as bone mesenchymal stem cells (BMSCs), into scaffolds provide an optimal method to repair large bone defects [3]. Bioceramics are crucial components for bone tissue engineering applications and have been widely studied [4]. Β-tricalcium phosphate (β-Ca3(PO4), TCP) is commonly used for hard tissue repair [5]. It is famous for its remarkable biocompatibility and osteoconductivity and its similarity in composition to natural bone [5]. It can be used as scaffold for delivery of cells and growth factors
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