Abstract
Propranolol HCl pellets were prepared in a rotor-granulator by layering the drug powder onto nonpareil seeds. They were then coated with Aquacoat® (an aqueous dispersion of ethylcellulose) in fluid bed coating machines, i.e., Aeromatic Strea I or Glatt GPCG-1, using different spray modes and/or chamber geometries. Dissolution data and morphology studies of coated pellets indicated differences in the nature of the coatings. This phenomenon may be attributed to differences in the particle motion in the bed, particle distribution and density in the coating zone, as well as the direction and the distance the sprayed droplets traverse prior to impinging on the particles. In addition, bed load and substrate frriability also appeared to affect the deposition of coating. Therefore, it is essential that for controlled-release coatings, the optimization of the fluid bed process be preceded by a careful evaluation of the spray mode and chamber geometry for a given piece of equipment.
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