Abstract
Bilateral injections of dibutyryl cyclic adenosine-3',5'-monophosphate (dibutyryl cyclic AMP), in a dose of 1 μg per injection, into the anterior hypothalamus of the conscious New Zealand White rabbit, produced a fever (0.8 ± 0.1 °C) with a short latency of onset (3.8 ± 1.5 min). Prior administration of a bolus of sodium salicylate followed by a constant infusion failed to reduce the dibutyryl cyclic AMP-induced hyperthermia. This is consistent with previously reported data supporting a role for cyclic AMP in the pathogenesis of PGE 1 fevers.
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