Effect of sodium salicylate on induced lipolysis in isolated fat cells of the rat

Abstract

The effect of sodium salicylate on fatty acid and glycerol release in vitro was examined in fat cells isolated from epididymal adipose tissue of fasted rats. Incubations were performed in the absence of glucose. Sodium salicylate reduced the rate of release of both glycerol and fatty acids induced by DL-arterenol, glucagon, theophylline, ACTH, dexamethasone plus growth hormone, and high and low concentrations of dibutyryl cyclic AMP plus theophylline. These findings suggest that sodium salicylate is a non-specific inhibitor of lipolysis in the adipose tissue cell. Sodium salicylate may inhibit the activation of triglyceride lipase by cyclic AMP or may directly inhibit the triglyceride lipase enzyme system. These findings are also compatible with the hypothesis that the decrease of plasma free fatty acids caused by salicylates in vivo is caused by direct action on adipose tissue.