The effect of sleeve gastrectomy on physiological functions and some vital indicators in obese patients in Najaf

Abstract

Abstract Background: Obesity usually results from excessive nutrition, which causes a defect in the functions of the immune system as a result of the accumulation of fat, as excess fat in the body is associated with changes in the number of white blood cells, red blood cells, and platelets, and is associated with changes in the function of the thyroid gland, where obesity affects the permeability of vessels It is also related to many metabolic disorders, including iron balance disorders, so many surgical techniques have been developed to treat obesity, including the laparoscopic sleeve gastrectomy, which is one of the common procedures for treating obesity and has gained great popularity due to its great impact on weight. This study aimed to know the complications and some side effects (positive and negative) of one of the surgeries used in the treatment of obesity, represented by sleeve gastrectomy Materials and Methods: Samples were collected from patients with laparoscopic sleeve gastrectomy who underwent the operation at Al-Batool Al-Ahly Hospital and Al-Ghadeer Center in Al-Najaf Governorate from September 2022 to March 2023. (43) Patients who underwent laparoscopic sleeve gastrectomy were selected (18) males and (25) Females aged between (60-18) years and with a body mass index greater than 35 kg / m2, (19) obese people (8) males and (11) females were taken as a control group, matching patients with age Results: The results showed a decrease in Ferritin protein levels and an increase in TSH levels in the patient group compared to the control group without statistical differences. As for blood indicators, the study showed that there were no significant differences (P>0.05) in the following indicators Hgb, HCT , MCV, and MCH, showed an increase in PLTs, MCHC, RBCs, MPV, and a decrease in WBC, Neutro, and Lymph in the patient group compared to the control group. As for the effect of gender on the criteria in the patient group, the results showed a significant decrease in both ferritin and each of Hgb. RBCs, HCT, MCV, MCH and MPV, and a significant increase in the level of TSH in females compared to males, and the results indicated that there were some changes in the studied parameters of sleeve gastrectomy patients divided according to the period after the operation. Conclusion: Although there was no significant difference between ferritin protein levels in the control group and the patients group, the protein levels decreased after gastric sleeve gastrectomy, and its levels were affected by sex and body mass index, and the sleeve gastrectomy was of high quality, clear effects with regard to some blood physiological parameters, especially a decrease in the number of white blood cells, neutrophils, and lymphocytes, which may indicate a decrease in low-grade inflammation resulting from obesity in the sleeved patients.