Abstract
Five different calmodulin antagonists, calmidazolium, trifluoperazine, chloroproazine, W-7 and W-5, were tested for inhibition of plasma membrane redox reactions on cultures carrot cells. Their effects varied. NADH oxidation was inhibited about 50% by calmidazolium and W-7, while the inactive form, W-5, stimulated NADH oxidation. Proton excretion by cultured carrot cells was totally inhibited by 40 μM calmidazolium, but it was differentially inhibited by trifluoperazine. Twenty micromolar trifluoperazine inhibited the basal rate of proton excretion 100%; 50 μM trifluoperazine inhibited about 90% of the redox-associated proton excretion. Inhibition of plasma membrane redox reactions and associated proton excretion by a few selected calmodulin antagonists may point to the association of Ca 2+-calmodulin as second messengers leading to cell growth.
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