The Effect of Rosmarinic Acid Against Ovarian and Lung Injuries Induced by Ovarian Torsion Detorsion in Rats

Abstract

Background: Here, we purposed to find out the effects of two different Rosmarinic acid (RA) doses against lung injury caused by ovarian ischemia-reperfusion. Materials and Methods: We planned the groups as sham, ovarian torsion detorsion (O/TD; 3hours torsion/3hours detorsion), RA 40 mg/kg (40 mg/kg RA+O/TD), and RA 80 mg/kg (80 mg/kg RA+O/TD) groups. Following the experimental procedure, we sacrificed the rats and then, collected the lung and ovarian tissues for biochemical evaluations. Result: Total oxidant status (TOS), myeloperoxidase (MPO) activity, malondialdehyde (MDA) levels, and oxidative stress index (OSI) were elevated in the O/TD group compared to the sham group. These parameters declined due to low and high doses of RA administration. Total antioxidant status (TAS) level and superoxide dismutase (SOD) activity diminished in the O/TD group while increasing in RA treatment groups. However, the high dose of RA treatment group enhanced the antioxidant activity further and reduced the oxidant parameters compared to the low dose RA treatment group. Conclusion: In this study, RA treatment reduced O/TD-induced ovarian and lung injuries in the experimental animals.