The Relationship Between Newly Derived Inflammatory Biomarkers from Hemogram and Serum Vitamin D Concentration in Pediatric Intensive Care Patients

Abstract

Introduction: Besides classical disorders of bone metabolism, vitamin D may explain the pathogenesis of many diseases associated with inflammation and vitamin D deficiency. While numerous studies support vitamin D's relationship with inflammation, some studies do not confirm this relationship. Novel Hemogram-Derived Inflammatory Biomarkers are new and inexpensive markers of inflammation that can be tested in all centers. The aim of this study is to investigate the relationship between 25-hydroxyvitamin D (25(OH)D) and new inflammatory markers and inflammation.
 
 Material and methods: This study was conducted prospectively and data from 77 patients treated in the Pediatric Intensive Care Unit were included. Simultaneous 25(OH)D3, calcium, phosphorus and complete blood count results were recorded. Novel hemogram-derived inflammatory biomarkers, systemic inflammatory response index (SIRI) and systemic immune inflammatory index (SII), were calculated.
 
 Results: There was no significant difference in hemogram-derived new inflammatory biomarkers between groups with and without vitamin D deficiency (p>0.05 for all).
 Conclusions: Our study did not reveal a statistical association between these inexpensive and universally available biomarkers and vitamin D levels and inflammation. The validity of the findings should be confirmed with a larger number of subjects.