Abstract
The effect of the thiophosphoroorganic insecticide ronnel and its oxygen analog on oxygen consumption by homogenates, and on succinate dehydrogenase and cytochrome oxidase activities in the mitochrondrial fractions of rat brain and liver, was investigated. A marked inhibition of blood plasma cholinesterase activity by the oxygen analog was demonstrated, but acetylcholinesterase activity was not affected. In contrast to its thiophosphoroorganic precursor, the oxygen analog caused a significant decrease in oxygen consumption by rat brain and liver homogenates and a decrease in cytochrome oxidase activity in both solubilized mitochondrial fractions. The succinate dehydrogenase activity was reduced only slightly by the oxygen analog in the brain fraction, but was marked in the liver fractions. The results suggest that the toxic activity of ronnel in vivo may be ascribed to its oxygen analog which appears as a metabolite of the former.
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