The Effect of Rehabilitation with Selected Concurrent Training on the Expression of Thrombospondin-1 and Interleukin-1 Beta in Blood Mononuclear Cells in Male Patients After Coronary Artery Bypass Graft Surgery

Abstract

Introduction and purpose: Coronary artery bypass graft (CABG) is a common therapeutic intervention that is performed in patients suffering from coronary heart diseases. The aim of this study was to determine the effect of selected combined rehabilitation exercises on the expression of thrombospondin-1 (TSP-1) and interleukin-1 beta (IL-1β) genes in patients after coronary artery bypass surgery. Method: In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd city) after coronary artery surgery were purposefully selected and available and randomly divided into two groups of combined exercise and control. Combined exercise program group performed aerobic (15-20 minutes with an intensity of 50-60% of the maximum heart rate) and resistance exercise (10-20 minutes, including three movements of the upper limbs and two movements of the lower limbs, each movement includes three sets and each set with 10 repetitions and 30 to 60 percent of a maximum repetition) for 10 weeks (30 sessions) and three sessions per week. Gene expression was measured by Real Time PCR method.. The data were analyzed using the Paired t-test and One-Way ANOVA at the P<0.05. Results: After the intervention period, a significant decrease in the expression of IL-1β was observed, but no significant difference was observed in the expression of TSP-1. Conclusion: Combined exercises as a non-pharmacological rehabilitation intervention can be useful in patients who have undergone CABG by reducing systemic inflammation.