The effect of regular exercise combined with quantitative nutritional support on immune function indicators such as CD3+, CD4+, CD8+, and nutritional status in dialysis patients.

Abstract

Abstract. To study the effect of regular exercise and quantitative nutri-tional support on dialysis patients’ immune function indicators and nutritional status, 100 uremic patients who underwent hemodialysis treatment in our hos-pital from February 2021 to February 2023 were selected as the study subjects. They were divided into a control group (n=50) that received regular exercise and routine nutritional support, and a research group (n=50) that received regular exercise and quantitative nutritional support. This study compared the baseline levels of nutritional indicators such as prealbumin (PA), transferrin (TF), serum albumin (SAB), and hemoglobin (HB); cellular immune indicators such as CD3+, CD4+, and CD8+; as well as humoral immune indicators such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) at enrollment and after three months of intervention. At the time of enrollment, there were no significant differences in nutritional indicators be-tween the two groups of patients (p>0.05), nor in the levels of cellular immune indicators (p>0.05) or humoral immune indicators (p>0.05). After three months of intervention, nutritional indicators such as PA in all patients in the experiment grew (p<0.05), and those in the research group exceeded the con-trol group (p<0.05). Similarly, the levels of CD3+ and other cellular immune indicators and the concentrations of IgA and other humoral immune indicators increased in both groups after three months of intervention (p<0.05). Howev-er, these increases were higher in the research group than in the control group (p<0.05). Regular exercise combined with quantitative nutritional support can effectively improve hemodialysis patients’ nutritional index levels, nutritional status, immune index levels, and immune function.