Abstract
Abstract. The etiology of depression, a prevalent psychiatric disorder, remains elusive. Depression often manifests as a sleep disturbance. A significant proportion of individuals suffering from depression exhibit various sleep rhythm problems. There occurs a well-established and intricate bidirectional association between sleep rhythm abnormalities and depression. The prefrontal cortex (PFC) has been demonstrated to have a crucial role in the development of depression in recent years. The PFC plays a crucial role in the regulation of several cognitive, emotional, behavioral, and other significant activities. The atypical functioning of the PFC might result in the disruption of the sleep cycle. Unusual neuronal activity in the PFC could play a crucial role in controlling both sleep problems and depression. This paper presents a comprehensive overview of the research methods employed in studying the PFC in animal models. It also investigates the potential neural mechanism by which reduced PFC neuron activity may impact sleep rhythm via the PFC-LH-HPA loop. By doing so, this study offers novel insights and concepts that contribute to a deeper comprehension of the underlying causes of depression. Furthermore, this research introduces a prospective approach for addressing depression and sleep disorders through the manipulation of PFC neuron activity, while also highlighting its medical implications and obstacles.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call