The Effect of Pulsatile Blood Flow During Proximal Graft, on Liver Function in Coronary Artery Bypass Graft Surgery

Abstract

Background: Liver dysfunction is a rare complication with high mortality and morbidity in coronary artery bypass grafting (CABG) surgery. Pulsatile blood flow probably maintains liver function during cardiopulmonary bypass (CPB). Methods: In this randomized clinical trial study, 68 patients who were underwent CABG surgery divided in two groups: pulsatile and non-pulsatile groups. We transferred continuous blood flow to pulsatile blood flow during proximal graft by using cardiac contraction. Results: There was not significant difference in serum-alanine-aminotransferase (SGPT) and alkaline phosphatase (ALP) values at variable times in two groups. In addition, the procedure of SGPT and ALP in the case and control groups was not significantly different in three days. There was not significant difference in serum glutamic oxaloacetic transaminase (SGOT) values at variable times in two groups. However, the procedure of SGOT in the case group was significantly increased and in control group was not significantly different in three days. Conclusion: we conclude that hemodynamic stability is more important than type of blood flow in maintaining liver function. K e y w o r ds: pulsatile perfusion, cardio pulmonary bypass, liver function