Abstract
Background: Prostaglandin E1 has been reported to benefit patients with significant peripheral vascular disease and limb threatening ischemia. The present retrospective study attempts to assess the effect of Prostaglandin E1 on ankle brachial index in non reconstructable symptomatic peripheral artery disease patients. Objectives: To study the effect of Prostaglandin E1 on ankle brachial index in non reconstructable symptomatic peripheral artery disease patients. Methods: Case records of 40 patients who had completed at least six cycles of injection were obtained from medical records of vascular surgery. The demographic data and the ankle brachial index of these patients were recorded at baseline and at the end of six cycles of the drug. Results: The average ABI of both the limbs changed significantly from baseline to the end of study after six cycles of Prostaglandin E1 injection (p<0.05). There was significant increase in Ankle brachial index for the symptomatic limb from baseline whereas the contra lateral limb did not show a significant change. There was a significant increase in Ankle brachial index of both limbs as well as the average Ankle brachial index in the patients without any co-morbidities conditions than those with the presence of co-morbidities. Conclusion: Prostaglandin E1 therapy increases the ankle brachial index in symptomatic limb of patients with non reconstructable symptomatic peripheral artery disease patients.
Highlights
The overall prevalence of Peripheral arterial disease (PAD) in Indian population is 3% [1] and among diabetic patients it is as high as 14% [2]
PAD is a marker of systemic atherosclerosis and is found more frequently among persons with wellknown cardiovascular risk factors, especially older age, smoking, or diabetes mellitus, or those with atherosclerosis in other vascular beds
The baseline characteristics and the ankle brachial index (ABI) at the baseline and at the end of 6 monthly injections of prostaglandin were recorded in a case record form
Summary
The overall prevalence of Peripheral arterial disease (PAD) in Indian population is 3% [1] and among diabetic patients it is as high as 14% [2]. Up to 20% of elderly individuals have PAD upon non-invasive testing [3]. Intermittent claudication is the earliest and the most frequent presenting symptom in patients with lower extremity PAD. PAD is a marker of systemic atherosclerosis and is found more frequently among persons with wellknown cardiovascular risk factors, especially older age, smoking, or diabetes mellitus, or those with atherosclerosis in other vascular beds. Prostaglandin E1 has been reported to benefit patients with significant peripheral vascular disease and limb threatening ischemia. The present retrospective study attempts to assess the effect of Prostaglandin E1 on ankle brachial index in non reconstructable symptomatic peripheral artery disease patients
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