Abstract
The actions of PGI 2 and PGE 2 on electrically monitored ion transport in rat jejunum and colon have been determined both in vivo and in vitro . Whilst PGE 2 was shown to induce a marked change in ion transport PGI 2 was relatively ineffective. The ability of the prostanoids to influence ion transport is related to their capacity to change mucosal cyclic AMP levels since in isolated small intestinal enterocytes PGE 2 caused a marked stimulation in cyclic AMP levels whilst PGI 2 had little effect. In colonic mucosal scrapes PGE 2 was more effective than PGI 2 in stimulating changes in cyclic AMP levels. It appears doubtful that PGI 2 plays a direct role in the regulation of intestinal ion transport.
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