Abstract
The effect of administration of Probenecid and hydrochlorothiazidc on renal clearances of free and conjugated 17-OHCS, total 17-KS, androsteronc (AND) and dehydroepiandrosterone (DEA) has been determined in normal human subjects. The data obtained suggest that the administration of Probenecid causes a sharp fall in the clearance of the 17-KS and mainly of AND, a less marked decrease in the clearance of the conjugated 17-OHCS, and no modification of the clearance of free 17-OHCS. The administration of hydrochlorothiazide in contrast, resulted in a marked increase in the clearance of all steroids measured, particularly AND and conjugated 17-OHCS. In the patients treated with long-acting ACTH and hydrochlorothiazidc, the hormonal clearances, already high at the beginning, as a result of ACTH administration, tended to increase to even a greater extent as compared to the patients receiving hydrochlorothiazide alone, especially in the case of AND. The authors have drawn the conclusion that it is possible to influence the plasma levels of steroids by pharmacological agents acting at the renal level.
Published Version
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