Abstract
The effect of pretreatment with pentobarbital, meperidine, or hyperbaric oxygen on the pattern of response to subsequent anoxia and survival on resuscitation was studied in newborn rabbits. Pentobarbital and meperidine prolonged primary apnea and the time to last gasp, whereas the over-all pattern of reaction to anoxia was similar in the rabbits pretreated with hyperbaric oxygen and in the controls. Pentobarbital in high doses increased the percentage recovery of rabbits compared with controls; there was no difference in survival after meperidine or pentobarbital in sedating doses. The group pretreated with hyperbaric oxygen had a significantly lower rate of survival than the control rabbits. This adverse effect on survival was prevented by the prior administration of sedating doses of pentobarbital.
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