Abstract
ObjectiveThe aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on the rate of implantation and pregnancy in women with repeated failed implantation during frozen embryo transfer. MethodsThis study was conducted on 50 infertile women candidates (who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj) with a history of failed implantation for the purpose of frozen embryo transfer. The participants were randomly divided into two groups (n = 25). In the first group (control), the intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer. In the second group (treatment), the intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer. ResultsIn this study, there was no significant difference between the two groups in the rate of chemical and clinical pregnancy. The rate of chemical pregnancy was 28% in the treatment group and 36% in the control group, while the rate of clinical pregnancy was 28% in the treatment group and 24% in the control group. ConclusionThe intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of failed implantation will not make any significant effect on the result of pregnancy.
Highlights
15% of couples suffer from infertility [1]
This study was conducted on infertile women who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj city 2018 to 2019 and were candidates for frozen embryo transfer cycle
This study was conducted on 50 infertile women who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj city
Summary
15% of couples suffer from infertility [1]. Infertility imposes many psychological, physical, and emotional problems on families and can have destructive effects on the social foundation of the family. Different methods have been proposed for the treatment of infertility. Despite the existence of such different methods for assisted reproductive technology (ART), the implantation of many embryos faces failure [3, 4, 5, 6, 7, 8]. In the period of endometrial receptivity, cytokines, growth factors, prostaglandins, and various binding molecules are secreted in the endometrium. One of the most important factors in embryo implantation is the appropriate condition of the endometrium [8, 9]. According to the European Society of Human Reproduction and Embryology, repeated implantation failure (RIF) is the lack of gestational sac in the 5-week old sonogram after three separate embryo transfers [10, 11]
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