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Abstract
The ideal antiviral agent would be one which, while inhibiting growth of the virus, had little or no toxic effect on a host cell. That such a compound with anti herpes virus activity appeared to exist was first shown by Shipkowitz et al. (1973) who in random screening experiments discovered the antiviral activity of phosphonoacetic acid (PAA). These early findings indicated that the compound was active against herpes simplex virus as herpes dermatitis in mice and herpes keratitis in rabbits, with little apparently serious effect on the animals themselves. Details of chemical structure are discussed by Dr Fox elsewhere in this supplement.
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