The effect of percutaneous coronary intervention after thrombolysis on cardiac function and serum levels of MMP-9 and PS in patients with AMI

Abstract

Objective To investigate the effect of percutaneous coronary intervention (PCI) after thrombolysis on cardiac function and serum levels of matrix metalloproteinase-9 (MMP-9) and P-selectin (PS) in patients with acute myocardial infarction (AMI). Methods 64 patients with AMI admitted to our hospital from September 2016 to October 2018 were randomly divided into observation group and control group, 32 cases in each group. The control group was treated with direct PCI within 90 minutes after admission, while the observation group was treated with intravenous thrombolysis before selective PCI. The therapeutic effects of the two groups were compared. Results IRA recanalization rate and relief rate of chest pain in the observation group were significantly higher than those in the control group (P<0.05); after 30 days of treatment, the level of LVEF in the observation group was significantly higher than that in the control group (P<0.05); 5 days after PCI, the levels of MMP-9 and PS in the observation group were significantly lower than those in the control group (P<0.05). Conclusion PCI after thrombolysis can effectively improve myocardial reperfusion in a short time, protect cardiac function, and significantly reduce serum MMP-9 and PS levels in patients with AMI. Key words: Intravenous thrombolysis; Percutaneous coronary intervention; Acute myocardial infarction; Cardiac function