Abstract
Objective: The aim was to assess the effect of the oral-care program and Kin Care mouthwash on the rate and severity of chemotherapy-induced oral mucositis (OM) in pediatric and adolescent cancer patients. 
 Methods: A randomized clinical trial study was conducted from May 2018 through May 2019. It was held in the Children Cancer Center of Hiwa Oncology and Hematology Hospital and included 48 participants aged 5-17 years who received chemotherapy. They were randomly allocated into either intervention or control groups; 24 patients each. The control group did not receive oral-care protocol intervention except for symptomatic measures. In contrast, the intervention group was provided with oral-care instructions and Kin Care mouthwash. Clinical evaluations were performed before commencing chemotherapy and then, twice per week, for three consecutive weeks. The World Health Organization Mucositis grading, the visual analog scale, oral hygiene status, and drinking and eating abilities were assessed.
 Results: There were no statistically significant differences between the two groups concerning age, gender, and tumor type. The most severe grades of OM (Grade III-IV) among the intervention group were significantly less than the control group (2.1% versus 22.9%). Besides, the use of Kin Care mouthwash decreased the occurrence of OM into half. The risk ratio of developing OM (Grades II-IV) was 0.51. 
 Conclusions: Regular oral-care program and Kin Care solution for children receiving chemotherapy effectively decreases the rate and severity of OM.
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