Abstract
The brain-derived neurotrophic factor (BDNF) is crucial for the metabolic and mental health of an individual. Numerous intervention experiments with the goal of increasing BDNF levels have been conducted as a result of the fact that higher concentrations are linked to better cognitive function. In order to obtain a better viewpoint from them, this study was conducted as the first study in this field, with the aim of comprehensively investigating the effects of omega-3 supplementation on BDNF. Scopus, PubMed/Medline, Web of Science, and Embase databases or platform were searched using standard keywords to identify all controlled trials investigating the BDNF effects of omega 3 supplementation. Pooled weighted mean difference and 95% confidence intervals were achieved by random-effects model analysis for the best estimation of outcomes. We used the Egger's test to determine whether there was publication bias. Eleven studies with 698 participants’ were included in this study. Results of random-effects meta-analysis indicated that BDNF levels were significantly increased after supplementation with omega 3 compared with the control group (pooled WMD of 1.01 μmol/L; 95% confidence interval [CI] 0.35 to 1.67; P =0.003; I2 = 97.7%) and this increase was even greater with intervention duration >10 weeks and doses ≤1500 mg/day. In addition, the effect of omega-3 supplementation on increasing glucose levels was greater in people under 50 years of age and patients with psychological diseases. In general, the present systematic review and meta‐regression analysis demonstrated that omega 3 supplementation may be able to significantly improve BDNF.
Published Version
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