Abstract
Norepinephrine decreased the mean rate of digital flow and the basal and maximal rates of pulsatile flow to the digit of man, as recorded rheoplethysmographically. Evidence was also obtained which indicated that the postcapillary vessels as well as the precapillary vessels were constricted by norepinephrine. It seems likely that norepinephrine “squeezes” blood from the venules and small veins toward the heart and lungs, accounting in part for the increase in central venous volume and pressure. The tone of the larger vessels is also increased by the drug. These events could be detrimental to the patient in congestive heart failure with high central venous pressure and blood volume.
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