The effect of Naoxintong capsule treatment on carotid artery intima-media thickness, serum beta thromboglobulin, P-selectin and plasminogen activator inhibitor-1 in elderly type 2 diabetic patients with subclinical atherosclerotic vascular disease

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Objective To investigate the effects of Naoxintong Capsule treatment on the carotid artery intima-media thickness(IMT), plasma beta thromboglobulin(beta-TG), P-selectin(CD62p)and plasminogen activator inhibitor-1(PAI-1)in elderly patients with type 2 diabetes mellitus and subclinical atherosclerotic vascular disease. Methods In retrospective study, 110 cases of elderly patients with type 2 diabetic vascular diseases were selected and admitted as study subjects from June 2014 to May 2015.They were randomized into observation group and control group(n=55, each). All patients were given routine treatment.The patients in the observation group were treated with Naoxintong Capsule.The levels of plasma β-TG, CD62p and PAI-1 were measured and compared between two groups. Results Before treatment, there were no significant differences in IMT, PAI-1, β-TG and CD62p levels between the two groups(P>0.05). After treatment, the observation group versus control group showed an improved four parameters of carotid artery IMT(1.31 ±0.26)mm vs.(1.44 ±0.26)mm, PAI-1(2.23 ±0.48)μg/L vs.(2.56 ±0.61)μg/L, β-TG(29.76 ± 10.24)μg/L vs.(35.98 ± 10.35)μg/L, CD62p(162.3 ± 21.5)ng/L vs.(176.96 ± 20.3)ng/L(t=4.058, 3.965, 11.293, 14.624 respectively, all P<0.05)with statistically significant differences. Conclusions Naoxintong Capsule treatment of type 2 diabetic patients with subclinical atherosclerotic vascular disease can reduce carotid intima-media thickness, decrease platelet releasing activity and lower the oxidative stress reaction.Thereby, it protects the vascular endothelium, and alleviates subclinical atherosclerotic vascular disease in the elderly type 2 diabetic patients. Key words: Diabetes mellitus, type 2; P-selectin; Plasminogen activator inhibitor 1