Abstract
Depression is a worldwide disease which has a great impact on peoples mental health and social functioning. Finding the factor causing depression is the precondition of treatment. This area has been investigated by enormous researchers. This paper reviews the researches about depression, including the effect of depression on brain, the relationship between tryptophan hydroxylase 2 (TPH2) and depression and treatment. These references indicate that depression can affect the structure of brain, including synaptic plasticity and hippocampal volumetric changes and so on. Mutated TPH2 is a major reason of depression. This mutation will inhibit the expression of TPH2 and affect the produce of serotonin. Moreover, researchers are able to use mice to do experiments on TPH2, because TPH2 is conserved between human and mice. Medication can be used to treat depression and its the main way to treat it. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) can also be used to treat it, but now it has some technical problems in treating human and also have some ethical problem because it will change patients gene.
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