Abstract
The effects of αMSH on beta adrenergic receptor response of rat pineal cells were studied in vitro. Responses measured were membrane hyperpolarization, measured with a micro-electrode, and cyclic AMP formation, measured by radio immunoassay. Normal resting membrane potential of pineal cells is approximately -40mV. Addition of NE produces a dose-dependent hyperpolarization of these cells. The addition of αMSH in vitro produces a very slight, but significant, depolarization, and markedly attenuates subsequent NE responses. αMSH has no effect on the cyclic AMP content of pineal glands, but again attenuates the action of NE in producing increased cellular cyclic AMP. These results suggest that αMSH may modulate pineal responsiveness.
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