The effect of molixan, a disulfide-containing immunomodulator, on Na<sup>+</sup> transport across frog skin epithelium

Abstract

The effect of molixan, a disulfide-containing immunomodulator which is an analogue of oxidized glutathione, on Na+ transport across frog skin epithelium has been studied. Using the voltage-clamp technique, the capacity of molixan to modulate Na+ transport across frog skin epithelium has been revealed for the first time. It was also found that when molixan is applied to the apical surface of frog skin, it suppresses Na+ transport, while molixan added on the basolateral surface may mimic the effect of insulin and stimulate Na+ transport. The results obtained indicate that oxidized glutathione and its analogs molixan and glutoxim unidirectionally modulate Na+ transport across frog skin.