Abstract
AbstractThe effect of moisture content of microcrystalline cellulose (MCC) on the compression properties of systems containing this diluent, has been examined. The formulations used included a product containing 97% MCC and two MCC based direct compression systems containing 49.5% paracetamol and 68% potassium phenethicillin. The MCC used contained moisture levels ranging from 0.6 - 7.3%. The tablets were made on an instrumented machine in conditions of relative humidity not exceeding 40%. The following tablet MCC are well documented, little has been published on the effect of moisture on its compressional characteristics. Also since it is common industrial practice to dry excipient before use with moisture sensitive drugs, a study of the effect of MCC on its compressional, disintegration and dissolution properties should be useful.
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