Abstract
Background and Aim. In traditional medicine, the use of Trachyspermum ammi, commonly known as 'Ajwain', is recommended to improve digestive function of the stomach and has effects on body weight. The present study aims to determine the effect different concentrations of mixed organic solvents extract (MOSE) of Trachyspermum ammi on mice compared with control group.
 
 Materials and Methods. This experimental-interventional study was performed on mice weighing an average of 21 gr, selected through random allocation method. The mice were divided into four groups of 24 (one control group and three case groups), receiving 0.5, 1 and 2% concentrations or density of MOSE of Trachyspermum ammi (0.001 mg/kg). First, the dried fruit of Trachyspermum ammi was powdered and then, it was extracted using various organic solvents including petroleum ether, chloroform, ethyl acetate and ethyl alcohol. The extract was fed to the mice for 14 days and their weight was controlled every day.
 
 Results. The hypothesis of diversity in the weight gain of mice among the four groups after 15 days was significant; weight gain in control group was significantly higher than other groups (p<0.05). In addition, comparing the weight gain of the mice that received different concentrations of MOSE of Trachyspermum ammi (0.5, 1 and 2%) did not show a significant difference (p<0.05).
 
 Conclusion. The use of Trachyspermum ammi plant can not be effect on body weight compared to the control group. This could not be a suitable way to weight change through diet.
Highlights
Trachyspermum ammi is a medicinal herb which is used to cure central nervous system (CNS) involvement, gastrointestinal disorders such as nausea, vomiting, abdominal cramps and loss of appetite, reduces the pain (Markesbery, 1997; Mohanty, 2017; Sivropoulou et al, 1996)
The use of Trachyspermum ammi plant can not be effect on body weight compared to the control group
The hypothesis of diversity in the weight gain of mice after 15 days was evaluated among the four study groups using
Summary
Trachyspermum ammi is a medicinal herb which is used to cure central nervous system (CNS) involvement, gastrointestinal disorders such as nausea, vomiting, abdominal cramps and loss of appetite, reduces the pain (Markesbery, 1997; Mohanty, 2017; Sivropoulou et al, 1996). This plant is broadly distributed and cultivated in many areas of Mediterranean countries and Iran, Afghanistan, Pakistan, Egypt, and India as well as European region(Bairwa, Sodha, & Rajawat, 2012). The present study aims to determine the effect different concentrations of mixed organic solvents extract (MOSE) of Trachyspermum ammi on mice compared with control group
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