Abstract
Euthyroid rats given metronidazole for30 days had no significant alteration in body or thyroid weight, but had a significant depression of pituitary weight. However, the pituitary TSH content was not affected. Hypothyroid rats given metronidazole developed smaller goiters than controls, but the difference was not statistically significant. The serum TSH level of rats receiving metronidazole was significantly less than controls being 0.12 mU/ml. vs. 0.44 mU/ml. When net TSH synthesis was measured (see Method) metronidazole treatment significantly reduced synthesis from 212 mU/24 hrs. to 145 mU/24 hrs. These findings in rats are consistent with the claim that metronidazole inhibits TSH secretion and thyroid function in man. Euthyroid rats given metronidazole for30 days had no significant alteration in body or thyroid weight, but had a significant depression of pituitary weight. However, the pituitary TSH content was not affected. Hypothyroid rats given metronidazole developed smaller goiters than controls, but the difference was not statistically significant. The serum TSH level of rats receiving metronidazole was significantly less than controls being 0.12 mU/ml. vs. 0.44 mU/ml. When net TSH synthesis was measured (see Method) metronidazole treatment significantly reduced synthesis from 212 mU/24 hrs. to 145 mU/24 hrs. These findings in rats are consistent with the claim that metronidazole inhibits TSH secretion and thyroid function in man.
Published Version
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