Abstract
It has been shown that the thyroid hormone accelerates the metabolism of all cells in the body. Under the influence of thyroxine, the metabolism of carbohydrates, proteins, fats, minerals and water are all modified (Kendall, 1939). In conjunction with investigations on the influence of the thyroid hormone on the oxidative enzymes, the succinoxidase system – which is an essential link in the citric acid cycle of Krebs, the common pathway for the terminal metabolism of carbohydrates, proteins and fats – has also been investigated. It has been shown by biochemical methods that the administration of desiccated thyroid, thyroxine or thyrotrophic hormone results in a marked rise in the activity of the succinoxidase system in rat liver slices (Tipton & Nixon, 1946, Barker et al., 1949, Tipton, 1950). The increase in enzymatic activity after the administration of thyroid hormone is also noticeable in thyroidectomized animals (Lipner & Barker, 1953); it is closely correlated with the time of administration (Barker & Klitgaard, 1952), but does not occur in vitro (Smith & Williams-Ashman, 1949).
Published Version
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